Abstract
Minced or cut-up leaves of Chinese chive (Allium tuberosum Rottler) contain thiosulfinates and their disproportionate reaction products. Among these organosulfur compounds, methyl methanethiosulfinate was found to be an uncompetitive inhibitor of β-glucuronidase. Approximately 80% of the enzyme activity was inhibited by methyl methanethiosulfinate at 50 µM, the IC50 value being comparable to 3.6 µM.
MeSH terms
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Allyl Compounds / chemistry
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Bacterial Proteins / antagonists & inhibitors*
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Bacterial Proteins / chemistry
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Chive / chemistry*
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Disulfides / chemistry
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Enzyme Assays
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Glucuronidase / antagonists & inhibitors*
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Glucuronidase / chemistry
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Kinetics
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Plant Leaves / chemistry*
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Solutions
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Sulfinic Acids / chemistry*
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Sulfinic Acids / isolation & purification
Substances
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Allyl Compounds
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Bacterial Proteins
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Disulfides
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Solutions
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Sulfinic Acids
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methyl methanethiosulfinate
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dimethyl disulfide
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diallyl disulfide
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Glucuronidase