Abstract
The mTOR protein kinase controls anabolic processes as part of mTOR complexes 1 and 2 (mTORC1 and mTORC2). The two complexes are now shown to be involved in a negative feedback regulatory mechanism, in which mTORC1 stimulation inactivates mTORC2 through the inhibitory phosphorylation of the mTORC2 component Sin1.
MeSH terms
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Adaptor Proteins, Signal Transducing / metabolism*
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Carcinogenesis*
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Humans
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Mechanistic Target of Rapamycin Complex 2
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Multiprotein Complexes / metabolism*
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Proto-Oncogene Proteins c-akt / metabolism*
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Signal Transduction*
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TOR Serine-Threonine Kinases / metabolism*
Substances
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Adaptor Proteins, Signal Transducing
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MAPKAP1 protein, human
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Multiprotein Complexes
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Mechanistic Target of Rapamycin Complex 2
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Proto-Oncogene Proteins c-akt
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TOR Serine-Threonine Kinases