Differences in gene expression between clonal variants of Mycobacterium tuberculosis emerging as a result of microevolution

Laura Pérez-Lago; Yurena Navarro; Marta Herranz; Emilio Bouza; Darío García-de-Viedma

doi:10.1016/j.ijmm.2013.09.010

Differences in gene expression between clonal variants of Mycobacterium tuberculosis emerging as a result of microevolution

Int J Med Microbiol. 2013 Dec;303(8):674-7. doi: 10.1016/j.ijmm.2013.09.010. Epub 2013 Oct 11.

Authors

Laura Pérez-Lago¹, Yurena Navarro, Marta Herranz, Emilio Bouza, Darío García-de-Viedma

Affiliation

¹ Servicio de Microbiología y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; CIBER Enfermedades Respiratorias-CIBERES (CD06/06/0058), Spain.

PMID: 24189285
DOI: 10.1016/j.ijmm.2013.09.010

Abstract

Clonal variants of Mycobacterium tuberculosis can emerge as a result of microevolution in a single host or after sequential infection of different hosts. The significance of subtle genotypic variations is still unknown. In three of the four loci analyzed from clonal variants differing in only one MIRU-VNTR locus, we found that the expression of the adjacent genes was modulated differently. These data highlight the potential advantages that acquisition of subtle variability may have in M. tuberculosis.

Keywords: MIRU-VNTR; Microevolution; Tuberculosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gene Expression Profiling
Gene Expression Regulation, Bacterial*
Genetic Variation
Humans
Mycobacterium tuberculosis / genetics*
Mycobacterium tuberculosis / isolation & purification*
Tuberculosis