Abstract
An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemotherapeutic. This study demonstrates the specific delivery of a platinum drug to mitochondria and investigates the effects of directing this agent outside the nucleus.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Nucleus / drug effects
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Cell Proliferation / drug effects
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Cisplatin / chemistry
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Cisplatin / pharmacology*
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DNA, Mitochondrial / drug effects*
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Dose-Response Relationship, Drug
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Female
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Humans
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Molecular Conformation
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Ovarian Neoplasms / drug therapy*
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Ovarian Neoplasms / pathology
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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DNA, Mitochondrial
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Cisplatin