Targeting mitochondrial DNA with a platinum-based anticancer agent

Chem Biol. 2013 Nov 21;20(11):1323-8. doi: 10.1016/j.chembiol.2013.08.010. Epub 2013 Oct 31.

Abstract

An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemotherapeutic. This study demonstrates the specific delivery of a platinum drug to mitochondria and investigates the effects of directing this agent outside the nucleus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Nucleus / drug effects
  • Cell Proliferation / drug effects
  • Cisplatin / chemistry
  • Cisplatin / pharmacology*
  • DNA, Mitochondrial / drug effects*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Molecular Conformation
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / pathology
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • DNA, Mitochondrial
  • Cisplatin