Abstract
A recently described marine gliding bacterium Rapidithrix thailandica strain TISTR 1741 was isolated from biofilm specimen collected from the Andaman Sea in Thailand. Four liters fermentation broth of R. thailandica TISTR 1741 cultivated in VY/2 medium were extracted with methanol to yield a novel amino phenyl pyrrolidone derivative compound (1) with antibacterial activities. The chemical structure and physico-chemical properties of 1 were investigated by spectrometry techniques. Compound 1 exhibited selective inhibition against vancomycin-resistant Enterococcus faecalis (VRE) with the MIC of 5.97 mM.
MeSH terms
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Aniline Compounds / chemistry
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Aniline Compounds / isolation & purification
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Aniline Compounds / pharmacology*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Bacteroidetes / chemistry*
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Bacteroidetes / classification
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Bacteroidetes / isolation & purification
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Enterococcus faecalis / drug effects
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Microbial Sensitivity Tests
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Pyrrolidinones / chemistry
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Pyrrolidinones / isolation & purification
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Pyrrolidinones / pharmacology*
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Seawater / microbiology
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Spectrum Analysis
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Thailand
Substances
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Aniline Compounds
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Anti-Bacterial Agents
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Pyrrolidinones