Abstract
Suitably protected sialyl T(N) and 2,6-sialyl T tumor-associated carbohydrate antigen-derived amino acids have been prepared stereoselectively using an oxazolidinone-derived sialoside donor. These glycosylamino acids can be employed directly in the solid-phase synthesis of glycopeptides, as demonstrated by the efficient preparation of tumor-associated MUC1 glycopeptide fragments.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Tumor-Associated, Carbohydrate / biosynthesis*
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Antigens, Tumor-Associated, Carbohydrate / chemistry*
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Glycopeptides / chemical synthesis*
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Glycopeptides / chemistry
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Sialic Acids / chemistry*
Substances
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Antigens, Tumor-Associated, Carbohydrate
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Glycopeptides
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Sialic Acids
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sialosyl-Tn antigen