Abstract
We report the design, synthesis, characterization and evaluation of a novel class of γ-AApeptide one-bead-one-compound (OBOC) library, from which a small γ-AApeptide was identified to effectively prevent and disassemble Aβ aggregation.
MeSH terms
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Amyloid beta-Peptides / antagonists & inhibitors*
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Amyloid beta-Peptides / metabolism
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Combinatorial Chemistry Techniques*
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Humans
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Molecular Mimicry
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Peptide Fragments / chemistry*
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Peptide Fragments / pharmacology*
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Peptide Library*
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Protein Multimerization / drug effects*
Substances
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Amyloid beta-Peptides
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Peptide Fragments
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Peptide Library