Background: Aim of the study was to investigate the relationship of melanin pigment and inflammatory process within gingival tissues based on clinical and genetic analysis by differential display technique and DNA sequencing.
Materials and methods: Seventy gingival biopsy specimens were taken from individuals with melanin pigmentation as well as healthy and inflamed gingiva. Specimens were examined by differential display technique using six different arbitrary primers. Cloning, sequencing and sequence analysis for six different genes were performed.
Results: Gingival specimens with hyperpigmentation (clinical melanin score = 3) showed presence of both, down- and up-regulatory genes when compared with the gingival specimen with clinical melanin score 0. These genes may have a role in curtailing the progress of gingival inflammation associated with melanin hyperpigmentation.
Conclusion: Melanin hyper pigmentation may possess a defensive role against progress of gingival inflammation How to cite this article:Eid HA, Syed S, Soliman AN. The Role of Gingival Melanin Pigmentation in Inflammation of Gingiva, Based on Genetic Analysis. J Int Oral Health 2013; 5(4):1-7.
Keywords: Differential display technique; Gingiva; Melanin hyper pigmentation.