Novel bioactive amino-functionalized cellulose nanofibers

Macromol Rapid Commun. 2013 Nov;34(22):1767-71. doi: 10.1002/marc.201300588. Epub 2013 Oct 22.

Abstract

Amino-cellulose-based nanofibers are prepared by electrospinning of blended solutions of 6-deoxy-6-trisaminoethyl-amino (TEAE) cellulose and polyvinyl alcohol (PVA). The TEAE cellulose with a degree of substitution of 0.67 is synthesized via a nucleophilic displacement reaction starting from cellulose-p-toluenesulfonic acid ester. Several solution characteristics such as polymer concentration, electrical conductivity, and surface tension as well as setup parameters are investigated to optimize the ability of nanofiber formation. These parameters are evaluated using the rheological studies of the solutions. The nanofibers obtained are characterized by scanning electron microscopy (SEM) and show a high antimicrobial activity against Staphylococcus aureus and Klebsiella pneumoniae.

Keywords: amino cellulose; antimicrobial activity; electro­spinning; nanofibers.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Cellulose / chemistry*
  • Electric Conductivity
  • Klebsiella pneumoniae / drug effects
  • Nanofibers / chemistry*
  • Nanofibers / toxicity
  • Polyvinyl Alcohol / chemistry
  • Staphylococcus aureus / drug effects
  • Surface Tension

Substances

  • Anti-Bacterial Agents
  • Polyvinyl Alcohol
  • Cellulose