Abstract
The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC(50)s versus colon (HT29-AK and leukemia (HL60) cell lines.
Keywords:
Apoptosis; Leukaemia; Malaria.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antimalarials / chemical synthesis
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Antimalarials / chemistry*
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Antimalarials / pharmacology*
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Caspase 3 / metabolism*
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Cell Line, Tumor
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Dimerization
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Humans
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Malaria, Falciparum / drug therapy
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Neoplasms / drug therapy
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Plasmodium falciparum / drug effects
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Tetraoxanes / chemical synthesis
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Tetraoxanes / chemistry*
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Tetraoxanes / pharmacology*
Substances
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Antimalarials
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Antineoplastic Agents
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Tetraoxanes
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Caspase 3