Mechanisms of napelline action stimulating the regeneration of hemopoietic tissue in cytostatic myelosuppression

G N Zyuz'kov; V V Zhdanov; E V Udut; L A Miroshnichenko; E A Losev; E V Simanina; A V Chaikovskiy; N I Suslov; T N Povet'eva; A V Krapivin; Yu V Nesterova; V I Agafonov; M Yu Minakova; L A Stavrova; M G Danilets; A A Ligacheva; E S Trofimova; A N Ivanova; V E Goldberg; D V Reikchart; A M Dygai

doi:10.1007/s10517-013-2172-7

Mechanisms of napelline action stimulating the regeneration of hemopoietic tissue in cytostatic myelosuppression

Bull Exp Biol Med. 2013 Aug;155(4):439-42. doi: 10.1007/s10517-013-2172-7.

Affiliation

¹ Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. zgn@pharm.tsu.ru. G. N. Zyuz'kov.

PMID: 24143362
DOI: 10.1007/s10517-013-2172-7

Abstract

Pronounced regenerative effects of alkaloid napelline extracted from Aconitum baicalense on granulocytic hemopoiesis were revealed in the model of cytostatic myelosuppression. Activation of functions of hemopoietic progenitor cells along with increased feeder capacity of the stromal elements in the hemopoiesis inducing microenvironment with decreased levels mesenchymal progenitor cells in the bone marrow are the mechanisms underlying the hemostimulating action of this substance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aconitine / pharmacology
Animals
Bone Marrow / drug effects
Bone Marrow Cells / drug effects
Bone Marrow Cells / physiology
Cells, Cultured
Cytostatic Agents / pharmacology
Fluorouracil / pharmacology
Hematopoiesis / drug effects*
Mesenchymal Stem Cells / drug effects
Mesenchymal Stem Cells / metabolism
Mice, Inbred CBA
Myeloid Progenitor Cells / drug effects
Myeloid Progenitor Cells / physiology
Regenerative Medicine

Substances

Cytostatic Agents
napelline
Fluorouracil
Aconitine