A path forward for the chlamydial virulence factor CPAF

Microbes Infect. 2013 Dec;15(14-15):1026-32. doi: 10.1016/j.micinf.2013.09.008. Epub 2013 Oct 18.

Abstract

CPAF is a conserved and secreted protease from obligate intracellular bacteria of the order Chlamydiales. Recently, it was demonstrated that most of its host targets are an artifact of inaccurate methods. This review aims to summarize key features of CPAF and propose new approaches for evaluating its role in chlamydial pathogenesis.

Keywords: CPAF; Chlamydial virulence factors and pathogenesis; Substrates.

Publication types

  • Review

MeSH terms

  • Animals
  • Chlamydia / genetics
  • Chlamydia / immunology
  • Chlamydia / metabolism*
  • Chlamydia / pathogenicity
  • Endopeptidases / chemistry
  • Endopeptidases / genetics
  • Endopeptidases / immunology
  • Endopeptidases / metabolism*
  • Humans
  • Virulence Factors / chemistry
  • Virulence Factors / genetics
  • Virulence Factors / immunology
  • Virulence Factors / metabolism*

Substances

  • Virulence Factors
  • Endopeptidases
  • CPA factor