Riboswitches represent promising novel RNA structures for developing compounds that artificially regulate gene expression and, thus, bacterial growth. The past years have seen increasing efforts to identify metabolite-analogues which act on riboswitches and which reveal antibacterial activity. Here, we summarize the current inventory of riboswitch-targeting compounds, their characteristics and antibacterial potential.
Keywords: Adenine; FMN; Glucosamin-6-phosphate; Guanine; Lysine; Metabolite; Riboswitch; Ribozyme; TPP.
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