Abstract
In recent years, the development of microfluidic chip separation devices coupled to MS has dramatically increased for high-throughput bioanalysis. In this review, advances in different types of microfluidic chip separation devices, such as electrophoresis- and LC-based microchips, as well as 2D design of microfluidic chip-based separation devices will be discussed. In addition, the utilization of chip-based separation devices coupled to MS for analyzing peptides/proteins, glycans, drug metabolites and biomarkers for various bioanalytical applications will be evaluated.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Chromatography, Liquid / instrumentation
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Chromatography, Liquid / methods
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Drugs, Investigational / analysis*
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Electrophoresis, Capillary / instrumentation
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Electrophoresis, Capillary / methods
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Humans
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Mass Spectrometry / instrumentation
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Mass Spectrometry / methods
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Microfluidic Analytical Techniques / instrumentation*
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Microfluidic Analytical Techniques / methods
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Microfluidics / instrumentation*
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Microfluidics / methods
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Polysaccharides / isolation & purification*
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Proteins / isolation & purification*
Substances
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Drugs, Investigational
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Polysaccharides
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Proteins