A synthetic small molecule for targeted transcriptional activation of germ cell genes in a human somatic cell

Angew Chem Int Ed Engl. 2013 Dec 9;52(50):13410-3. doi: 10.1002/anie.201306766. Epub 2013 Oct 18.

Authors

Le Han¹, Ganesh N Pandian, Syed Junetha, Shinsuke Sato, Chandran Anandhakumar, Junichi Taniguchi, Abhijit Saha, Toshikazu Bando, Hiroki Nagase, Hiroshi Sugiyama

Affiliation

¹ Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502 (Japan); Shanghai Key Laboratory of Chemical Biology, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Meilong Road 130, Shanghai, 200237 (China).

PMID: 24136857
DOI: 10.1002/anie.201306766

No abstract available

Keywords: DNA recognition; genetic switches; polymerase chain reaction; proteins; synthetic biology.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Germ Cells / metabolism*
Humans
Hydroxamic Acids / chemical synthesis
Hydroxamic Acids / chemistry
Hydroxamic Acids / metabolism*
Hydroxamic Acids / pharmacology
Imidazoles / chemistry
Imidazoles / metabolism
Molecular Structure
Nylons / chemical synthesis
Nylons / chemistry
Nylons / metabolism*
Pluripotent Stem Cells / metabolism*
Pluripotent Stem Cells / pathology
Pyrroles / chemistry
Pyrroles / metabolism
Transcriptional Activation / drug effects
Transcriptional Activation / genetics*

Substances

Hydroxamic Acids
Imidazoles
Nylons
Pyrroles
imidazole