Abstract
The cardioprotective effects of necroptosis inhibitors necrostatin-1 and necrostatin-5 were studied on the isolated heart model in rats. Intraperitoneal injection of necrostatin-1 (1.65 mg/kg) or necrostatin-5 (2.46 mg/kg) 60 min before reperfusion of the isolated heart reduced the infarction zone caused by 30-min global ischemia and 120-min reperfusion. Intracoronary injection of necrostatin-1 (44.5 μmol/liter) caused an increase of left-ventricular systolic pressure, that is produced a positive inotropic effect, but did not reduce the infarction zone.
MeSH terms
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Animals
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Apoptosis / drug effects
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Blood Flow Velocity / drug effects
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Blood Pressure / drug effects
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Cardiotonic Agents / therapeutic use*
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Heart
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Heart Rate / drug effects
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Heterocyclic Compounds, 3-Ring / therapeutic use*
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Imidazoles / therapeutic use*
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Indoles / therapeutic use*
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Male
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Myocardial Infarction / drug therapy*
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Myocardial Reperfusion Injury / drug therapy*
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Nitriles / therapeutic use*
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Rats
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Rats, Wistar
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Ventricular Function, Left / drug effects
Substances
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Cardiotonic Agents
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Heterocyclic Compounds, 3-Ring
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Imidazoles
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Indoles
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Necrostatin-5
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Nitriles
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necrostatin-1