Norlathyrane diterpenes from the root of Euphorbia kansuensis

Chem Biodivers. 2013 Oct;10(10):1887-93. doi: 10.1002/cbdv.201300004.

Abstract

Phytochemical investigation of the EtOH extract obtained from the root of the Euphorbia kansuensis Proch. grown in China resulted in the isolation of two novel norlathyrane diterpenes, named ekanpenoids A and B (1 and 2, resp.). Their structures were established by extensive 1D- and 2D-NMR spectroscopy, as well as other spectra. The isolated diterpenes exhibited potent cytotoxic activities against the HeLa and Hep-G2 cell lines with the IC50 values ranging from 3.6 to 9.7 μg/ml.

Keywords: Cytotoxic activity; Diterpenes; Ekanpenoids A and B; Euphorbia kansuensis; Norlathyrane.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / toxicity
  • Cell Survival / drug effects
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / toxicity
  • Euphorbia / chemistry*
  • Euphorbia / metabolism
  • HeLa Cells
  • Hep G2 Cells
  • Humans
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Plant Roots / chemistry
  • Plant Roots / metabolism

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • ekanpenoid A
  • ekanpenoid B