CXCR4 in epidermal keratinocytes: crosstalk within the skin

Wendy B Bollag; William D Hill

doi:10.1038/jid.2013.271

CXCR4 in epidermal keratinocytes: crosstalk within the skin

J Invest Dermatol. 2013 Nov;133(11):2505-2508. doi: 10.1038/jid.2013.271.

Authors

Wendy B Bollag¹, William D Hill²

Affiliations

¹ Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia, USA; Department of Physiology, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Department of Medicine (Dermatology), Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Department of Cellular Biology & Anatomy, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Department of Orthopaedic Surgery, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Institute of Regenerative and Reparative Medicine, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA. Electronic address: WB@gru.edu.
² Charlie Norwood VA Medical Center, One Freedom Way, Augusta, Georgia, USA; Department of Cellular Biology & Anatomy, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Department of Orthopaedic Surgery, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA; Institute of Regenerative and Reparative Medicine, Medical College of Georgia at Georgia Regents University, Augusta, Georgia, USA.

Abstract

In this issue, Takekoshi et al. investigated the role of CXCR4 in IL-23-induced keratinocyte hyperproliferation using an epidermal-specific knockout mouse model and found that CXCR4 limited keratinocyte proliferation. Some reports in the literature support this idea, whereas others contradict it; this disparity may be related to the differential roles of CXCR4 in various cell types or to a recently identified second receptor (CXCR7). Nevertheless, CXCR4 and its ligand SDF-1 have been implicated in skin wound healing, systemic lupus erythematosus, and basal cell carcinoma tumor angiogenesis. Further study is merited.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Dermatitis / immunology*
Female
Humans
Interleukin-23 Subunit p19 / immunology*
Keratinocytes / immunology*
Male
Receptors, CXCR4 / immunology*

Substances

CXCR4 protein, human
CXCR4 protein, mouse
Il23a protein, mouse
Interleukin-23 Subunit p19
Receptors, CXCR4

Abstract

Publication types

MeSH terms

Substances

Grants and funding