Poly(meth)acrylate-based coatings

Int J Pharm. 2013 Dec 5;457(2):461-9. doi: 10.1016/j.ijpharm.2013.09.029. Epub 2013 Oct 12.

Abstract

Poly(meth)acrylate coatings for pharmaceutical applications were introduced in 1955 with the launch of EUDRAGIT(®) L and EUDRAGIT(®) S, two types of anionic polymers. Since then, by introducing various monomers into their polymer chains and thus altering their properties, diverse forms with specific characteristics have become available. Today, poly(meth)acrylates function in different parts of the gastrointestinal tract and/or release the drug in a time-controlled manner. This article reviews the properties of various poly(meth)acrylates and discusses formulation issues as well as application possibilities.

Keywords: Coating; Delayed release; Poly(meth)acrylates; Polymer; Sustained release; Taste masking.

Publication types

  • Review

MeSH terms

  • Chemistry, Pharmaceutical
  • Drug Compounding
  • Excipients / chemistry
  • Polymethacrylic Acids / chemistry*
  • Powders / chemistry

Substances

  • Excipients
  • Polymethacrylic Acids
  • Powders