Gastrointestinal sensitivity and gastroesophageal reflux disease

Ann N Y Acad Sci. 2013 Oct:1300:80-95. doi: 10.1111/nyas.12236.

Abstract

This paper reports on gastrointestinal sensitivity, including on the role of refluxate volume on the perception of reflux symptoms; experimental pain models that mimic mechanisms and symptoms of pain associated with esophageal diseases; the potential role of the acid receptor TRPV1 in the genesis of gastroesophageal reflux disease (GERD) symptoms; and roles for ATP and the purine and pyrimidine receptor subfamilies P1, P2X, and P2Y in the pathogenesis of GERD symptoms.

Keywords: ATP; GERD; PAR2; TRPV1; pain; purinergic receptors.

Publication types

  • Review

MeSH terms

  • Gastroesophageal Reflux / metabolism
  • Gastroesophageal Reflux / physiopathology*
  • Gastrointestinal Tract / metabolism
  • Gastrointestinal Tract / physiopathology*
  • Humans
  • Pain / metabolism
  • Pain / physiopathology*
  • Receptors, Purinergic / metabolism
  • TRPV Cation Channels / metabolism

Substances

  • Receptors, Purinergic
  • TRPV Cation Channels
  • TRPV1 protein, human