Targeted theranostic nanoparticles: receptor-mediated entry into cells, pH-induced signal generation and cytosolic delivery

Small. 2014 Mar 12;10(5):901-6. doi: 10.1002/smll.201302136. Epub 2013 Sep 18.

Abstract

Virus-like theranostic nanoparticles: virus-like poly(amino acid) nanoparticles are synthesized that can be internalized via receptor-mediated endocytosis, resulting in encapsulated pH-activatable fluorescence probes that can be turned on in acidic environments but otherwise remain undetectable. The encapsulated anticancer drugs are also released into cytosol by endosome disruption.

Keywords: cancer cells; fluorescence; hydrophobicity; polymeric nanoparticles; theranosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Membrane / metabolism
  • Cytosol / metabolism*
  • Drug Delivery Systems*
  • Fluorescence
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Molecular Imaging
  • Nanoparticles / therapeutic use*
  • Neoplasms / diagnosis*
  • Neoplasms / therapy*
  • Receptors, Cell Surface / metabolism*
  • Virus Internalization

Substances

  • Receptors, Cell Surface