25th anniversary article: interfacing nanoparticles and biology: new strategies for biomedicine

Adv Mater. 2014 Jan 22;26(3):359-70. doi: 10.1002/adma.201303001. Epub 2013 Sep 16.

Abstract

The exterior surface of nanoparticles (NPs) dictates the behavior of these systems with the outside world. Understanding the interactions of the NP surface functionality with biosystems enables the design and fabrication of effective platforms for therapeutics, diagnostics, and imaging agents. In this review, we highlight the role of chemistry in the engineering of nanomaterials, focusing on the fundamental role played by surface chemistry in controlling the interaction of NPs with proteins and cells.

Keywords: bionanotechnology; nano-bio interface; nanoparticles; stimuli responsive nanoparticles; surface functionality.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Anniversaries and Special Events
  • Cells / chemistry*
  • Drug Carriers / chemistry
  • Drug Carriers / therapeutic use
  • Humans
  • Nanoparticles / chemistry
  • Nanoparticles / therapeutic use*
  • Nanostructures / chemistry
  • Nanostructures / therapeutic use
  • Proteins / chemistry*
  • Surface Properties

Substances

  • Drug Carriers
  • Proteins