Cholesterol: fa(s)t-food for enterovirus genome replication

Jeroen R P Strating; Hilde M van der Schaar; Frank J M van Kuppeveld

doi:10.1016/j.tim.2013.09.007

Cholesterol: fa(s)t-food for enterovirus genome replication

Trends Microbiol. 2013 Nov;21(11):560-1. doi: 10.1016/j.tim.2013.09.007. Epub 2013 Oct 6.

Authors

Jeroen R P Strating¹, Hilde M van der Schaar, Frank J M van Kuppeveld

Affiliation

¹ Department of Infectious Diseases and Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, The Netherlands.

Abstract

Hijacking and remodeling of host membranes is an obligatory step in the replicative cycle of (+)RNA viruses, including enteroviruses. Ilnytska et al. unveiled in Cell Host & Microbe that enteroviruses usurp clathrin-mediated endocytosis to shuttle cholesterol to sites of genome replication and that cholesterol is needed for efficient replication.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cholesterol / metabolism*
Endocytosis*
Enterovirus / physiology*
Host-Pathogen Interactions*
Humans
Virus Replication*

Substances

Cholesterol