Background: Thromboembolism, including deep venous thrombosis and pulmonary embolism, is a grave threat to patients undergoing total joint replacement. Using a systematic review and meta-analysis we asked whether gene mutations or polymorphisms could be risk factors for thrombosis after arthroplasty.
Methods: We performed a comprehensive search of Medline, PubMed, Embase, Cochrane databases, China National Knowledge Infrastructure (CNKI), and Google Scholar, and identified 19 studies detailing genetic investigations of patients with thromboembolism following joint replacement.
Results: Our meta-analyses included 5149 patients who underwent arthroplasty surgery. Significant associations with venous thromboembolism were identified for factor G1691A (odds ratio (OR) 1.41, 95% confidence interval (CI) 1.03 - 1.94, p=0.03), prothrombin G20210A (OR 2.16, 95% CI, 1.27- 3.69, p=0.005), and MTHFR/C677T/TT (OR 2.36, 95% CI 1.03 - 5.42, p=0.04) in Caucasian populations. No significant gene mutation was identified in Asian populations.
Conclusion: This study suggests a way to identify patients scheduled for arthroplasty who are at higher risk of thrombosis, enabling individualized treatment.
Keywords: ACE; APC; Arthroplasty; CI; DVT; FLV; Gene; Genetic Susceptibility; I/D; MTHFR; Meta-analysis; OR; PAI-1; PE; Polymorphism; STREGA; STROBE; THA; TKA; Thromboembolism; VTE; activated protein C; confidence interval; deep venous thrombosis; encoding angiotensin-converting enzyme; factor V Leiden; insertion/deletion; methylenetetrahydrofolate Reductase; odds ratio; plasminogen-activator inhibitor 1; pulmonary embolism; strengthening the Reporting of Genetic Association Studies; strengthening the Reporting of Observational Studies in Epidemiology; total hip arthroplasty; total knee arthroplasty; venous thrombus embolism.
© 2013.