Bioactive protopanaxatriol type saponins isolated from the roots of Panax notoginseng (Burk.) F. H. Chen

Molecules. 2013 Aug 26;18(9):10352-66. doi: 10.3390/molecules180910352.

Abstract

Seven new protopanaxatriol type saponins, 20S-sanchirhinosides A1 (1), A2 (2), A3 (3), A4 (4), A5 (5), and A6 (6), and sanchirhinoside B (7) were obtained as minor constituents from the root extract of Panax notoginseng (Burkill, F. H. Chen), which showed protection effects against antimycin A induced mitochondrial oxidative stress. Their structures were elucidated by chemical and spectroscopic methods (IR, HRESI-TOF-MS, 1D and 2D NMR). Among them, compounds 4, 6 and 7 showed significant protective effects against antimycin A-induced L6 cell injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / chemistry*
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology
  • Cell Line
  • Cell Survival / drug effects
  • Chromatography, High Pressure Liquid
  • Drug Evaluation, Preclinical
  • Drugs, Chinese Herbal / chemistry*
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacology
  • Magnetic Resonance Spectroscopy
  • Models, Chemical
  • Molecular Structure
  • Oxidative Stress / drug effects
  • Panax notoginseng / chemistry*
  • Plant Roots / chemistry*
  • Rats
  • Sapogenins / chemistry
  • Saponins / chemistry*
  • Saponins / isolation & purification
  • Saponins / pharmacology
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Antioxidants
  • Drugs, Chinese Herbal
  • Sapogenins
  • Saponins
  • protopanaxatriol