1 Department of Medicine and Department of Clinical Epidemiology and Biostatistics, McMaster, University and St. Joseph's Hospital, Hamilton, ON, Canada Intensive Care Unit, Royal Perth Hospital, and School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia Department of Intensive Care Medicine, Raymond Poincaré, Hospital (AP-HP), School of Medicine Simone Veil, University of Versailles SQY, Garches, France Department of Medicine, Cooper Medical School of Rowan University and Cooper University Hospital, Camden, NJ.