Abstract
Necroptosis is mediated by engagement of RIP kinases and a downstream pseudokinase, MLKL. In this issue of Immunity, Murphy et al. (2013) show that it operates at or close to the final execution mechanism of the death process.
Copyright © 2013 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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Apoptosis*
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Protein Kinases / metabolism*
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Receptor-Interacting Protein Serine-Threonine Kinases / metabolism*
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Tumor Necrosis Factors / metabolism*
Substances
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Tumor Necrosis Factors
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MLKL protein, mouse
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Protein Kinases
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Receptor-Interacting Protein Serine-Threonine Kinases
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Ripk3 protein, mouse