A mild, selective copper-catalyzed oxidative phosphonation of α-amino ketones

Bin Yang; Ting-Ting Yang; Xi-An Li; Jun-Jiao Wang; Shang-Dong Yang

doi:10.1021/ol402355a

A mild, selective copper-catalyzed oxidative phosphonation of α-amino ketones

Org Lett. 2013 Oct 4;15(19):5024-7. doi: 10.1021/ol402355a. Epub 2013 Sep 20.

Authors

Bin Yang¹, Ting-Ting Yang, Xi-An Li, Jun-Jiao Wang, Shang-Dong Yang

Affiliation

¹ State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China, and State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics , Lanzhou 730000, P. R. China.

PMID: 24053610
DOI: 10.1021/ol402355a

Abstract

A novel and selective method of simple copper-salt catalyzed phosphonation of α-amino carbonyl compounds to afford imidoylphosphonates is reported. This reaction system has a broad reaction scope. The convenient and environmentally benign process makes this protocol very attractive.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Copper
Ketones / chemistry*
Molecular Structure
Organophosphorus Compounds / chemical synthesis*
Organophosphorus Compounds / chemistry
Oxidation-Reduction
Stereoisomerism

Substances

Ketones
Organophosphorus Compounds
Copper