Abstract
Of 235 Mycobacterium tuberculosis isolates from patients who had not received tuberculosis treatment in the Irkutsk oblast and the Sakha Republic (Yakutia), eastern Siberia, 61 (26%) were multidrug resistant. A novel strain, S 256, clustered among these isolates and carried eis-related kanamycin resistance, indicating a need for locally informed diagnosis and treatment strategies.
Keywords:
HIV; MDR TB; MIRU-VNTR; Russian Federation; Siberia; genotype; multidrug-resistant tuberculosis; mycobacterial interspersed repetitive unit; pncA; pyrazinamide; tuberculosis; tuberculosis and other mycobacteria.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Amidohydrolases / genetics
-
Amino Acid Substitution
-
Antitubercular Agents / pharmacology
-
Bacterial Proteins / genetics
-
Bacterial Typing Techniques
-
Catalase / genetics
-
Cluster Analysis
-
DNA Gyrase / genetics
-
DNA-Directed RNA Polymerases
-
Drug Resistance, Multiple, Bacterial / genetics
-
Genes, Bacterial
-
Humans
-
Minisatellite Repeats
-
Multilocus Sequence Typing
-
Mycobacterium tuberculosis / genetics*
-
Oxidoreductases / genetics
-
Pentosyltransferases / genetics
-
Prevalence
-
Siberia / epidemiology
-
Tuberculosis, Multidrug-Resistant / epidemiology
-
Tuberculosis, Multidrug-Resistant / microbiology*
-
Tuberculosis, Pulmonary / epidemiology
-
Tuberculosis, Pulmonary / microbiology*
Substances
-
Antitubercular Agents
-
Bacterial Proteins
-
rpoB protein, Mycobacterium tuberculosis
-
Oxidoreductases
-
Catalase
-
katG protein, Mycobacterium tuberculosis
-
InhA protein, Mycobacterium
-
EmbB protein, Mycobacterium tuberculosis
-
Pentosyltransferases
-
DNA-Directed RNA Polymerases
-
Amidohydrolases
-
PncA protein, Mycobacterium tuberculosis
-
DNA Gyrase