Past research has devoted little attention to the role of work routine (i.e., adherence to a consistent pattern of attending work in a regular, predictable manner) in civilians' lives during wartime. The current study offers competing theoretical arguments on how work routine and gender combine to moderate the association between primary appraisal and war-related stress among civilians during the second Lebanon war (July-August 2006). Data were collected using telephone interviews (based on a structured questionnaire) with 2072 civilians. The sample was obtained using a within-strata random-sampling method. Our results suggest that negative affect (a symptom of stress) is associated with more negative primary appraisal of the war situation (i.e., higher threat appraisal). The association between negative affect and appraisal was attenuated among individuals engaging in regular work routine and among men. Moreover, the positive relationship between work routine and appraisal was stronger among women than among men. This study provides insight into the role of the workplace in the lives of civilians exposed to continuing in unsafe situations. In light of the past research suggesting that women are more vulnerable to war-related stress than men, this study proposes that regular work routine may be particularly beneficial for women.