Abstract
A series of 6-deoxymollugins were prepared five steps from benzaldehyde and its derivatives via phenylboronic acid-catalyzed chromenylation as a key step. Their inhibitory activities against tyrosinase from mushroom were evaluated to show that the parent, methyl 2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate (9a) showed best and promising inhibitory activity at IC50 = 18.3 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agaricales / enzymology
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Cell Line, Tumor
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Drugs, Chinese Herbal / chemical synthesis*
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology
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Humans
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Monophenol Monooxygenase / antagonists & inhibitors*
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Monophenol Monooxygenase / metabolism
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Pyrans / chemical synthesis*
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Pyrans / isolation & purification
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Pyrans / pharmacology
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Rubiaceae*
Substances
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Drugs, Chinese Herbal
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Enzyme Inhibitors
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Pyrans
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rubimaillin
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Monophenol Monooxygenase