Electrophile induced branching cascade: a powerful approach to access various molecular scaffolds and their exploration as novel anti-mycobacterial agents

Chem Commun (Camb). 2013 Oct 3;49(86):10109-11. doi: 10.1039/c3cc45289a.

Abstract

Herein we report on the Electrophile Induced Branching Cascade (EIBC), a new technique to produce a variety of biologically important molecular scaffolds. Some compounds exhibit excellent activities against Mycobacterium smegmatis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Chemistry, Pharmaceutical / methods*
  • Drug Evaluation, Preclinical
  • Molecular Structure
  • Mycobacterium smegmatis / drug effects*
  • Small Molecule Libraries / chemical synthesis
  • Small Molecule Libraries / chemistry
  • Small Molecule Libraries / pharmacology
  • Stereoisomerism

Substances

  • Anti-Bacterial Agents
  • Small Molecule Libraries