Systematic investigation of DNAs with modified cytosines under hot alkali treatment

Tian Tian; Xiaoe Zhang; Boshi Fu; Yuelin Long; Shuang Peng; Shaoru Wang; Xiang Zhou; Xin Zhou

doi:10.1039/c3cc45423a

Systematic investigation of DNAs with modified cytosines under hot alkali treatment

Chem Commun (Camb). 2013 Nov 4;49(85):9968-70. doi: 10.1039/c3cc45423a.

Authors

Tian Tian¹, Xiaoe Zhang, Boshi Fu, Yuelin Long, Shuang Peng, Shaoru Wang, Xiang Zhou, Xin Zhou

Affiliation

¹ College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Wuhan, Hubei 430072, P. R. China. xzhou@whu.edu.cn srwang@whu.edu.cn.

PMID: 24042448
DOI: 10.1039/c3cc45423a

Abstract

We have conducted the first systematic investigation of DNAs with modified cytosines, including 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC), under hot alkali treatment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

5-Methylcytosine / chemistry
Alkalies / chemistry
Cytosine / chemistry*
DNA / chemistry*
Hot Temperature*
Molecular Structure

Substances

Alkalies
5-Methylcytosine
Cytosine
DNA