A concise synthesis of (+)-salvadione B

Org Lett. 2013 Oct 4;15(19):4924-7. doi: 10.1021/ol402010r. Epub 2013 Sep 16.

Abstract

The novel hexacyclic triterpene salvadione B was synthesized in seven steps from the chiral quinone shown. The insight gained from this synthesis permitted a two-step, one-pot sequence to introduce the three additional rings and seven chiral centers.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Benzoquinones / chemistry*
  • Molecular Structure
  • Stereoisomerism
  • Triterpenes / chemical synthesis*
  • Triterpenes / chemistry

Substances

  • Benzoquinones
  • Triterpenes
  • salvadione B