Coiled-coil peptide motifs as thermoresponsive valves for mesoporous silica nanoparticles

Giuliana Martelli; Harshal R Zope; Mireia Bròvia Capell; Alexander Kros

doi:10.1039/c3cc45790g

Coiled-coil peptide motifs as thermoresponsive valves for mesoporous silica nanoparticles

Chem Commun (Camb). 2013 Nov 4;49(85):9932-4. doi: 10.1039/c3cc45790g.

Authors

Giuliana Martelli¹, Harshal R Zope, Mireia Bròvia Capell, Alexander Kros

Affiliation

¹ Leiden Institute of Chemistry, Leiden University, P.O. Box 2300, RA Leiden, The Netherlands. a.kros@chem.leidenuniv.nl.

PMID: 24037026
DOI: 10.1039/c3cc45790g

Abstract

Coiled-coil peptide motifs were used as thermo-responsive valves for mesoporous silica nanoparticles (MSNs). The controlled release of a model drug as a function of temperature was demonstrated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Delayed-Action Preparations
Fluorescein / chemistry
Models, Biological
Nanoparticles / chemistry*
Peptides / chemistry*
Porosity
Protein Structure, Tertiary
Silicon Dioxide / chemistry*
Temperature*

Substances

Delayed-Action Preparations
Peptides
Silicon Dioxide
Fluorescein