Abstract
A facile three step synthesis of a group of N1,N5-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides, N1,N5-bis[4-(1,2,4-oxadiazol-3-yl)phenyl]glutaramide and N1,N5-bis[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]glutaramide is described. These products are designed to function as masked bis-amidine prodrugs of a promising N1,N5-bis[4-(N'-(carbamimidoyl)phenyl]glutaramide antifungal lead.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / metabolism
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Glutarates / chemical synthesis*
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Glutarates / metabolism
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Microsomes, Liver / metabolism
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Oxadiazoles / chemical synthesis*
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Oxadiazoles / metabolism
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Oximes / chemical synthesis*
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Oximes / metabolism
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Prodrugs / chemical synthesis*
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Prodrugs / metabolism
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Rats
Substances
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Antifungal Agents
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Glutarates
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Oxadiazoles
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Oximes
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Prodrugs