Abstract
Bioassay-guided isolation of an aqueous methanolic extract of Vitis vinifera using pancreatic lipase inhibitory activity led to isolation of seven stilbenoids, wilsonol C (1), heyneanol A (2), ampelopsin A (3), pallidol A (4), cis-piceid (5), trans-piceid (6) and trans-resveratrol (7). The structures were established on the basis of NMR and MS spectroscopic data interpretation. All isolates were evaluated for their inhibitory effects on pancreatic lipase, and stilbenoid 1 exhibited potent inhibitory effect on pancreatic lipase with IC₅₀ values of 6.7 ± 0.7 µM.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Obesity Agents / chemistry
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Anti-Obesity Agents / isolation & purification
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Anti-Obesity Agents / pharmacology*
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Drug Discovery*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Ethnopharmacology
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Kinetics
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Lipase / antagonists & inhibitors*
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Lipase / metabolism
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Pancreas / enzymology
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Roots / chemistry*
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Republic of Korea
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Stilbenes / chemistry
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Stilbenes / isolation & purification
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Stilbenes / pharmacology*
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Sus scrofa
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Vitis / chemistry*
Substances
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Anti-Obesity Agents
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Enzyme Inhibitors
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Plant Extracts
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Stilbenes
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wilsonol C
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Lipase