Iron-catalyzed one-pot 2,3-diarylquinazolinone formation from 2-nitrobenzamides and alcohols

Org Lett. 2013 Sep 20;15(18):4900-3. doi: 10.1021/ol402350x. Epub 2013 Sep 9.

Abstract

A novel approach for the synthesis of 2,3-diarylquinazolinones using iron as catalyst is described. Various 2-nitro-N-arylbenzamides reacted with benzylic alcohols to selectively give the corresponding products in the absence of external oxidant or reductant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols / chemistry*
  • Benzamides / chemistry*
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Iron / chemistry*
  • Molecular Structure
  • Nitro Compounds / chemistry*
  • Quinazolinones / chemical synthesis*
  • Quinazolinones / chemistry

Substances

  • Alcohols
  • Benzamides
  • Nitro Compounds
  • Quinazolinones
  • Iron