Syntheses and anti-tubercular activity of β-substituted and α,β-disubstituted peptidyl β-aminoboronates and boronic acids

Abstract

Tuberculosis is still affecting millions of people worldwide, and new resistant strains of Mycobacterium tuberculosis are being found. It is therefore necessary to find new compounds for treatment. In this paper, we report the synthesis and in vitro testing of peptidyl β-aminoboronic acids and β-aminoboronates with anti-tubercular activity.

Keywords: Matteson homologation; antibacterial peptides; beta-aminoboronates; beta-aminoboronic acids; peptidyl beta-aminoboronates; peptidyl beta-aminoboronic acids; tuberculosis.