CMP-sialic acid transporter: We report an in-depth, multidisciplinary, structural study that has identified the amino acid residues intimately involved in CMP-sialic acid transporter (CST) substrate specificity. Our data provide a significant contribution towards a better understanding the structure-function relationship of this important family of transporters and the rational design of CST inhibitors.
Keywords: CMP-sialic acid transporter; NMR spectroscopy; nucleotide sugar transporters; sialic acids; site-directed mutagenesis.
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