Abstract
A gold nanorod (GNR) based LSPR sensor has been developed for label-free detection of C-reactive protein (CRP). The sensor utilizes a single chain variable fragment (scFv) as a receptor to bind CRP. The results of this effort show that CRP in human serum can be quantitatively detected at lower than 1 ng mL(-1).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Blood Chemical Analysis / methods*
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C-Reactive Protein / chemistry*
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C-Reactive Protein / metabolism
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Gold / chemistry
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Humans
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Limit of Detection
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Nanotubes / chemistry
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Single-Chain Antibodies / chemistry*
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Single-Chain Antibodies / metabolism
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Surface Plasmon Resonance*
Substances
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Single-Chain Antibodies
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Gold
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C-Reactive Protein