Rs290487 of TCF7L2 gene is not associated with type 2 diabetes in Chinese Han population: a case control study and meta-analysis

Abstract

Aims: rs290487 in TCF7L2 was originally identified to be associated with type 2 diabetes in Taiwan Chinese population. However, discrepancies were noted in subsequent replicated studies. So the aim of this study is to investigate the effect of rs290487 in TCF7L2 on genetic susceptibility of type 2 diabetes in a large sample of Chinese -population.

Results: In meta analysis of 9 studies with 9 422 cases and 8 585 control subjects, no association was found between rs290487 and type 2 diabetes in China (OR=1.06, 95% confidence interval (CI), 0.96-1.17, p=0.19). In case control study, rs290487 was genotyped in 5 151 diabetic patients and 4 650 non-diabetic controls. After adjusting for sex, age and BMI, and using an additive genetic model, logistic regression analysis revealed no association between rs290487 and type 2 diabetes (OR=1.015, 95%CI 0.949-1.087, p=0.662). No association was found between rs290487 and type 2 diabetes in northern and southern Chinese population separately.

Conclusions: In summary, we have found no association between rs290487 and type 2 diabetes in Chinese population. This SNP is unlikely an influential genetic variant with type 2 diabetes in Chinese population.