Abstract
Bioinspired poly(dopamine) (PDA) films are merged with antifouling poly(MeOEGMA) brushes utilizing a nitrile imine-mediated tetrazole-ene cycloaddition (NITEC)-based phototriggered surface encoding protocol. The antifouling brushes were photopatterned on PDA surfaces, leading cells to form confluent layers in the non-irradiated sections, while no adhesion occurred on the brushes resulting in a remarkably precise cell pattern. The presented strategy paves the way for the design of tailor-made patterned cell interfaces.
Keywords:
antifouling polymer brushes; micropatterning; nitrile imine-mediated tetrazole-ene cycloaddition (NITEC); photoligation; poly(dopamine).
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acrylates / chemistry
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Acrylates / metabolism
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Animals
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Cell Adhesion Molecules / genetics
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Cell Adhesion Molecules / metabolism
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Cell Adhesion*
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Cell Line
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Green Fluorescent Proteins / genetics
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Green Fluorescent Proteins / metabolism
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Indoles / chemistry*
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Indoles / metabolism
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Microfilament Proteins / genetics
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Microfilament Proteins / metabolism
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Phosphoproteins / genetics
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Phosphoproteins / metabolism
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Polyethylene Glycols / chemistry
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Polyethylene Glycols / metabolism
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Polymers / chemistry*
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Polymers / metabolism
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Rats
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Recombinant Fusion Proteins / biosynthesis
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Recombinant Fusion Proteins / genetics
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Silicon / chemistry
Substances
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Acrylates
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Cell Adhesion Molecules
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Indoles
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Microfilament Proteins
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Phosphoproteins
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Polymers
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Recombinant Fusion Proteins
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poly(oligoethylene glycol methyl ether acrylate)
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polydopamine
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vasodilator-stimulated phosphoprotein
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Green Fluorescent Proteins
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Polyethylene Glycols
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Silicon