MEX-3 proteins: recent insights on novel post-transcriptional regulators

Trends Biochem Sci. 2013 Oct;38(10):477-9. doi: 10.1016/j.tibs.2013.08.004. Epub 2013 Aug 30.

Abstract

RNA-binding proteins of the evolutionarily-conserved MEX-3 family are mediators of post-transcriptional regulation in different organisms. Recent studies highlight their involvement in diverse physiological settings, including the maintenance of a balance between stem cell self-renewal and differentiation. Here, we draw attention to their putative role in tissue homeostasis and disease, particularly cancer.

Keywords: CDX2; MEX-3; RNA-binding protein; carcinogenesis; development; post-transcriptional regulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / immunology
  • Caenorhabditis elegans Proteins / metabolism*
  • Humans
  • Protein Biosynthesis*
  • RNA / genetics*
  • RNA / metabolism
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / immunology
  • RNA-Binding Proteins / metabolism*

Substances

  • Caenorhabditis elegans Proteins
  • MEX-3 protein, C elegans
  • MEX3C protein, human
  • RNA-Binding Proteins
  • RNA