Analysis of the coverage capacity of the StreptInCor candidate vaccine against Streptococcus pyogenes

Vaccine. 2014 Jul 7;32(32):4104-10. doi: 10.1016/j.vaccine.2013.08.043. Epub 2013 Aug 27.

Abstract

Streptococcus pyogenes is responsible for infections as pharyngitis, sepsis, necrotizing fasciitis and streptococcal toxic shock syndrome. The M protein is the major bacterial antigen and consists of both polymorphic N-terminal portion and a conserved region. In the present study, we analyzed the in vitro ability of StreptInCor a C-terminal candidate vaccine against S. pyogenes to induce antibodies to neutralize/opsonize the most common S. pyogenes strains in Sao Paulo by examining the recognition by sera from StreptInCor immunized mice. We also evaluated the presence of cross-reactive antibodies against human heart valve tissue. Anti-StreptInCor antibodies were able to neutralize/opsonize at least 5 strains, showing that immunization with StreptInCor is effective against several S. pyogenes strains and can prevent infection and subsequent sequelae without causing autoimmune reactions.

Keywords: Immune response; Immunization coverage; Rheumatic fever; Streptococcus pyogenes; Vaccine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Bacterial / blood
  • Antibodies, Neutralizing / blood
  • Antigens, Bacterial / immunology*
  • Autoimmunity
  • Cross Reactions
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Mitral Valve / immunology
  • Phagocytosis
  • Streptococcal Infections / prevention & control*
  • Streptococcal Vaccines / immunology*
  • Streptococcus pyogenes*

Substances

  • Antibodies, Bacterial
  • Antibodies, Neutralizing
  • Antigens, Bacterial
  • Streptococcal Vaccines