Three new phenolics and other constituents from the seeds of Lithocarpus pachylepis

Molecules. 2013 Aug 28;18(9):10397-403. doi: 10.3390/molecules180910397.

Abstract

Twelve phenolics, including the three new compounds balanophonin C (1), balanophonin D (2), balanophonin E (3), were isolated from the seeds of Lithocarpus pachylepis. Their structures were elucidated by various spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). Compounds 1-9 were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 and showed moderate inhibitory activities, with IC₅₀ values ranging from 10.9 to 34.7 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Line
  • Drug Evaluation, Preclinical
  • Fagaceae / chemistry*
  • Inhibitory Concentration 50
  • Lipopolysaccharides / pharmacology
  • Macrophages / drug effects
  • Macrophages / immunology
  • Mice
  • Phenols / chemistry
  • Phenols / isolation & purification
  • Phenols / pharmacology*
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Seeds / chemistry*

Substances

  • Anti-Inflammatory Agents
  • Lipopolysaccharides
  • Phenols
  • Plant Extracts