Abstract
A series of N-pivaloyl-N'-(alkyl/aryl)-N''-pyridylguanidine of general formula C₄H₉CONHC(NR¹R²)NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synthesized guanidines were tested for antitumor activities against potato tumor, and showed excellent inhibition against Agrobacterium tumefaciens (AT10)-induced tumor. The antioxidant and antimicrobial activities of these new compounds against various bacterial and fungal strains were also investigated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemical synthesis
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Antifungal Agents / pharmacology*
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology*
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Biphenyl Compounds / chemistry
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Disk Diffusion Antimicrobial Tests / standards
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Drug Screening Assays, Antitumor
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Free Radical Scavengers / chemical synthesis
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Free Radical Scavengers / pharmacology*
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Free Radicals
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Guanidines / chemical synthesis
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Guanidines / pharmacology*
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Models, Molecular
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Molecular Conformation
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Picrates / chemistry
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Plant Tumors / microbiology
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Pyridines / chemical synthesis
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Pyridines / pharmacology*
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Reference Standards
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Vincristine / pharmacology
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X-Ray Diffraction
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Antineoplastic Agents
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Biphenyl Compounds
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Free Radical Scavengers
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Free Radicals
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Guanidines
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Picrates
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Pyridines
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Vincristine
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1,1-diphenyl-2-picrylhydrazyl