Abstract
The anaphase-promoting complex/cyclosome (APC/C) is restricted by metazoan protein early mitotic inhibitor 1 (EMI1), a natural, potent inhibitor. New findings suggest that the multimodal inhibitory mechanisms of EMI1 control APC/C-dependent ubiquitylation.
MeSH terms
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Anaphase-Promoting Complex-Cyclosome
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Antigens, CD
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Cadherins / chemistry*
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Cell Cycle Proteins / chemistry*
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F-Box Proteins / chemistry*
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Humans
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Ubiquitin-Protein Ligase Complexes / chemistry*
Substances
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Antigens, CD
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CDH1 protein, human
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Cadherins
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Cell Cycle Proteins
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F-Box Proteins
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FBXO5 protein, human
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Ubiquitin-Protein Ligase Complexes
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Anaphase-Promoting Complex-Cyclosome