EMI1, a three-in-one ubiquitylation inhibitor

Nat Struct Mol Biol. 2013 Jul;20(7):773-4. doi: 10.1038/nsmb.2626.

Abstract

The anaphase-promoting complex/cyclosome (APC/C) is restricted by metazoan protein early mitotic inhibitor 1 (EMI1), a natural, potent inhibitor. New findings suggest that the multimodal inhibitory mechanisms of EMI1 control APC/C-dependent ubiquitylation.

Publication types

  • News
  • Comment

MeSH terms

  • Anaphase-Promoting Complex-Cyclosome
  • Antigens, CD
  • Cadherins / chemistry*
  • Cell Cycle Proteins / chemistry*
  • F-Box Proteins / chemistry*
  • Humans
  • Ubiquitin-Protein Ligase Complexes / chemistry*

Substances

  • Antigens, CD
  • CDH1 protein, human
  • Cadherins
  • Cell Cycle Proteins
  • F-Box Proteins
  • FBXO5 protein, human
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome