Abstract
Four known compounds had been isolated from the Streptomyces sp. YIM66017, and their structures were elucidated by spectral analysis as 2,6-dimethoxy terephthalic acid (1), yangjinhualine A (2), α-hydroxyacetovanillone (3) and cyclo(Gly-Trp) (4). Compound 1 was isolated from natural resources for the first time, and compounds 2-4 were isolated from streptomycetes for the first time. The 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity assays showed that 1 showed higher activity than rutin with IC50 of 4.61 μg/mL and 2 showed the activity with IC50 of 57.12 μg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alpinia / microbiology
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Biphenyl Compounds / pharmacology
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Dipeptides / chemistry
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Dipeptides / isolation & purification
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology
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Inhibitory Concentration 50
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Molecular Structure
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification
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Phthalic Acids / chemistry
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Phthalic Acids / isolation & purification*
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Phthalic Acids / pharmacology
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Picrates / pharmacology
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Rutin / pharmacology
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Streptomyces / chemistry*
Substances
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2,6-dimethoxy terephthalic acid
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Biphenyl Compounds
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Dipeptides
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Free Radical Scavengers
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Peptides, Cyclic
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Phthalic Acids
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Picrates
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cyclo(glycyltryptophyl)
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Rutin
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1,1-diphenyl-2-picrylhydrazyl