Abstract
Seventeen bromotyrosine-derived metabolites, including eight new compounds, were isolated from a Micronesian sponge of the genus Suberea. Four of the new compounds were psammaplysin derivatives (10-13), and the other four were ceratinamine derivatives (14-17). Of the compounds obtained, the psammaplysins exhibited cytotoxicity against human cancer cell lines (GI₅₀ values down to 0.8 μM), while the ceratinamine and moloka'iamine analogues showed almost no activity. These results suggest that the spirooxepinisoxazoline ring system is a requirement for cytotoxicity and, therefore, may serve as an attractive molecular scaffold for the development of a potent anticancer agent.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Bromobenzenes / chemistry
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Bromobenzenes / isolation & purification*
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Bromobenzenes / pharmacology*
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Drug Screening Assays, Antitumor
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Formamides / chemistry
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Formamides / isolation & purification*
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Formamides / pharmacology*
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Humans
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Marine Biology
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Molecular Structure
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Nitriles / chemistry
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Nitriles / isolation & purification*
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Nitriles / pharmacology*
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Nuclear Magnetic Resonance, Biomolecular
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Porifera / chemistry*
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Spiro Compounds / chemistry
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Spiro Compounds / isolation & purification*
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Spiro Compounds / pharmacology*
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Tyrosine / analogs & derivatives*
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Tyrosine / chemistry
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Tyrosine / isolation & purification
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Tyrosine / pharmacology
Substances
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Antineoplastic Agents
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Bromobenzenes
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Formamides
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Nitriles
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Spiro Compounds
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bromotyrosine
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ceratinamine
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psammaplysin F
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Tyrosine